Activation of molecular oxygen by flavins and flavoproteins.
نویسندگان
چکیده
منابع مشابه
Activation of molecular oxygen by flavins and flavoproteins.
is essentially irreversible. In free solution the reaction is slow because of spin inversion associated with the reaction of singlet reduced flavin with triplet 0, and complex, as described below. With flavoproteins the reaction with 0, may be orders of magnitude faster or slower, depending on the specific flavoprotein or the class of flavoprotein to which i t belongs. Clearly the reactivity of...
متن کاملFluorescence properties of reduced flavins and flavoproteins.
Fluorescence lifetimes and polarized emission properties of reduced flavin were measured using several model compounds and flavoproteins. Depending on the conditions of solvent and temperature or reduction method the lifetimes vary between 1 and 15 ns. The longer lifetime values are found in several forms of reduced lactate oxidase, in which a good correlation exists between fluorescence intens...
متن کاملNew flavins for old: artificial flavins as active site probes of flavoproteins.
Flavin enzymes are unique as biological catalysts in that they carry out a wide variety of different biochemical processes. This sets them apart from enzymes which use other coenzymes, like pyridine nucleotides, pyridoxal phosphate or thiamin pyrophosphate, each of which involves a single type of chemical event. Flavins thus are involved in the dehydrogenation of a variety of substrates, in one...
متن کاملThe univalent reduction of oxygen by reduced flavins and quinones.
FMN and flavodoxin, when reduced by the action of ferredoxin-TPN+ oxidoreductase, have been shown to cause both univalent and divalent reductions of oxygen. Superoxide radicals, so generated, were detected by their abilities to oxidize epinephrine to adrenochrome and to reduce cytochrome c. Superoxide dismutase inhibited these actions of the superoxide radical. The ratio of the univalent reduct...
متن کاملThe enigmatic reaction of flavins with oxygen.
The reaction of flavoenzymes with oxygen remains a fascinating area of research because of its relevance for reactive oxygen species (ROS) generation. Several exciting recent studies provide consistent mechanistic clues about the specific functional and structural properties of the oxidase and monooxygenase flavoenzymatic systems. Specifically, the spatial arrangement of the reacting oxygen tha...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1994
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)31664-2